crocin alleviates the local paw edema induced by histamine in rats
نویسندگان
چکیده
objective: crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. the present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. materials and methods: local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hind paw. the thickness of paw was measured at 1 h before and 1, 2, 3 h after injection of histamine, using a fine caliper. the number of neutrophils in paw tissue sections was counted 3 h after intraplantar injection of histamine. results: intraperitoneal injection of crocin at doses of 100 and 200 mg/kg and chlorpheniramine at a dose of 10 mg/kg significantly (p<0.05) decreased both paw thickness and infiltration of neutrophils in paw tissues. in a combined treatment, intraperitoneal injection of an effective dose of crocin (100 mg/kg) with an ineffective dose of chlorpheniramine (2.5 mg/kg) produced a more documented response in comparison with crocin (100 mg/kg) and chlorpheniramine (2.5 mg/kg) used alone. conclusion: the results suggested that both crocin and chlorpheniramine suppressed histamine-induced local paw edema. moreover, histamine h1 receptors function may be affected by crocin.
منابع مشابه
Crocin alleviates the local paw edema induced by histamine in rats
Objective: Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. Materials and Methods: Local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hi...
متن کاملCrocin alleviates the local paw edema induced by histamine in rats
OBJECTIVE Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. MATERIALS AND METHODS Local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hin...
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In this study, the effects of separate and combined intraperitoneal (IP) injections of histidine and dexamethasone were investigated on local inflammation in rats. Local inflammation was induced by subcutaneous (SC) injection of histamine (100 μl, 0.1%) in ventral surface of right hind paw. The thickness of paw was measured at 30 min before and 30, 60, 90, 120, 150 and 180 min after injection o...
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عنوان ژورنال:
avicenna journal of phytomedicineجلد ۲، شماره ۲، صفحات ۹۷-۱۰۴
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